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KMID : 0358320100510110794
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Korean Journal of Urology
2010 Volume.51 No. 11 p.794 ~ p.799
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Effect of Korean Red Ginseng on Testicular Tissue Injury after Torsion and Detorsion
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Kim Young-Ho
Kim Gun-Hwa
Shin Ju-Hyun
Kim Kang-Sup
Lim Jae-Sung
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Abstract
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Purpose Korean red ginseng (KRG) is a potent antioxidant and a free radical scavenger. This study was designed to determine whether KRG could protect against dysfunction and oxidative stress induced by torsion-detorsion injury in rat testis.
Materials and Methods Six-week-old male Sprague-Dawley rats were randomly divided into four groups: a sham-operated control group (C), a sham-operated and KRG-treated group (K), a 2 hours torsion and detorsion group (T), and a 2 hours torsion and detorsion and KRG-treated group (T+K). We measured testis weight and hormone levels and reactive oxygen species (ROS) from the left renal vein. Superoxide generation was measured on the basis of lucigenin-enhanced chemiluminescence in testis tissue.
Results Testicular weight was significantly higher in the T+K group than in the T group; however, there were no significant differences in hormone levels between the 4 groups. The mean level of ROS and superoxide production was significantly higher in the T group than in the C group, whereas administration of KRG attenuated this increase. Upon histologic evaluation, the T group was found to have cellular disarray, a lack of cellular cohesiveness, degenerative changes in the germinal cells, and less distinct changes in the seminiferous tubules, whereas the T+K group had a germinal epithelial layer that appeared nearly normal.
Conclusions The present study demonstrated that KRG recovered the testis dysfunction in the rat testis by suppressing superoxide production.
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KEYWORD
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Ginseng, Oxidative stress, Testicular torsion
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